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Mammals produce cyclo-octasulphur to protect cells from lipid damage

Jim Cornall -
Elemental sulphur is well known in microorganisms, plants, and fungi, but whether mammals produce and use elemental sulphur has...

New antibiotic resistance mechanism discovered in superbug Pseudomonas aeruginosa

Jim Cornall -
A joint research team led by Hongbaek Cho of the Department of Biological Sciences at Sungkyunkwan University (SKKU) and...

Preclinical data demonstrate prime-editing correction of pathogenic BRCA1 splice-site mutation

Jim Cornall -
Origin Genomics has announced initial preclinical results from OG-101, its BRCA1 gene-correction research programme. The company screened three prime-editor...

Undecimal Bio launches with $18m to address ‘liver trap’ in siRNA therapeutic delivery

Jim Cornall -
Undecimal Bio, a platform biotechnology company advancing targeted delivery of siRNA therapeutics, has announced an oversubscribed $18m seed financing. The...

Technology inspired by 3D printing could transform how medicines are tailored to patients

Jim Cornall -
Many medicines today are produced in standard doses, even though patients often have very different treatment needs. In her...

Growing optical fibres using biology

Jim Cornall -
A new project led by Northumbria University aims to grow optical fibres using proteins, mimicking a process that has...

Base to Base biotech podcast 79: Fragile X syndrome and Parkinson’s disease

Jim Cornall -
This week, we chat with Simon Mølgaard, co-founder and chief executive officer of Teitur Trophics about results from its...

Novel cancer therapy blocks communication between cancer cells and cancer-associated fibroblasts

Jim Cornall -
A research team led by Yoosoo Yang of the Department of Integrative Biotechnology at Sungkyunkwan University (SKKU), in collaboration...

Retinitis pigmentosa cell therapy drug cleared for clinical trials in US and China

Jim Cornall -
iRegene Therapeutics Co., Ltd. has announced its investigational cell therapy NouvSight001 has received clearance from China's National Medical Products...

How cells fight back after bacterial toxins break through

Jim Cornall -
Bacterial toxins can create pores in epithelial cell membranes, threatening cell survival and weakening the body’s protective barriers. Yet...

New approach to treating chronic wounds

Jim Cornall -
The human body possesses the ability to heal itself. To do so, it replaces millions of old cells with...

Hidden amplification switch has implications for cancer metastasis

Jim Cornall -
Lymphatic vessels act as the body’s “drainage system,” collecting excess fluid from tissues. When lymphatic drainage is impaired because...

Recreating key features of the antibody factory in a dish

Jim Cornall -
Researchers at the University of Osaka have developed a simple culture method that converts B cells isolated from human...

FDA Orphan Drug Designation and Rare Pediatric Disease Designation for sarcoma drug

Jim Cornall -
UTR Therapeutics Inc. has announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD)...

Confidence boost for AI virtual cells for novel target discovery

Jim Cornall -
Shift Bioscience has published new research in Nature Biotechnology describing an improved calibration framework for deep learning-based genetic perturbation...

Anti-fibrotic drug could be repurposed to control cell communication

Jim Cornall -
An experimental anti-fibrotic compound can dramatically alter how cells release the microscopic packages they use to communicate, according to...

Positive data from oral therapy designed to improve muscle function and body composition

Jim Cornall -
Atrogi AB has announced positive data from a human trial for its lead candidate ATR-258, a first-in-class small molecule...

Pneumonia can reveal undiagnosed blood cancer

Jim Cornall -
Severe pneumococcal disease requiring hospitalisation, most commonly pneumonia, can be a sign of previously undiagnosed blood cancer and immunodeficiency...

Base to Base biotech podcast 78: A new treatment for erectile dysfunction, and nanotechnology for knee osteoarthritis

Jim Cornall -
This week, we chat with Lucas Decuypere, CEO and president of Allegro, about treatment of knee osteoarthritis with a...

Kovina Therapeutics awarded $2.3m grant for first-in-class HPV cancer therapy

Jim Cornall -
Kovina Therapeutics Inc., a biotech company developing first-in-class small molecule therapeutics targeting the human papillomavirus (HPV) E6 oncoprotein, has...

IL-23 inhibitor shows improvement in spinal pain and stiffness in axial psoriatic arthritis study

Jim Cornall -
Johnson & Johnson has announced that TREMFYA (guselkumab) met the primary and major secondary endpoints demonstrating both improvement in...