Spear Bio, a biotechnology company pioneering homogeneous ultrasensitive immunoassay technology, has announced the commercial launch of its SPEAR UltraDetect immunoassay solution for biomarker measurement.
The launch includes four assays, targeting key neurology biomarkers: phosphorylated tau 231 (pTau231), phosphorylated tau 217 (pTau217), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL). Spear Bio will collaborate with Bio-Techne to distribute SPEAR UltraDetect immunoassays globally.
Unlike traditional ultrasensitive technologies, which rely on heterogeneous formats that require solid surface capture and multiple wash steps, Spear Bio’s SPEAR technology is the first homogeneous immunoassay platform that achieves ultra-sensitivity without wash steps. It precisely quantifies protein biomarkers at attomolar concentrations from as little as 1µl of diluted sample.
SPEAR technology further addresses longstanding specificity challenges by eliminating the non-specific binding common in heterogeneous assays, reducing false-positive results. Its two-factor authentication mechanism ensures that signal arises only when antibody pairs are co-localized on target proteins over an extended period of time.
SPEAR UltraDetect immunoassays can be read on a range of qPCR systems adopted in research and clinical labs, with consistent results across different qPCR instruments and formats. This enables unique robustness, scalability, and ease of integration into existing laboratory workflows.
“We are proud to deliver the first of its kind ultrasensitive immunoassay solution that could potentially solve the challenges that neurology researchers working with blood-based biomarkers have faced for years,” said Feng Xuan, co-founder and CEO of Spear Bio.
“SPEAR UltraDetect will empower academic and clinical researchers worldwide to unlock new insights and improve therapies and treatments for a variety of neurological conditions.”
Jim Cornall is editor of Deeptech Digest and publisher at Ayr Coastal Media. He is an award-winning writer, editor, photographer, broadcaster, designer and author. Contact Jim here.
