Mursla Bio has launched its AI precision medicine platform.
It also issued a pre-print reporting the first validated method for isolating hepatocyte extracellular vesicles (EVs) from plasma for organ-specific proteomic and miRNA profiling. Mursla Bio is engaging with potential partners to apply its platform to additional disease areas, biomarker discovery and IVD translation programmes.
The platform addresses a gap in liquid biopsy and precision medicine: enabling non-invasive access to organ-specific molecular information from blood with high spatial and biological resolution. Mursla Bio’s platform is built on its ability to isolate and analyze EVs secreted by specific organs into the bloodstream. The platform reduces non-target background by up to five orders of magnitude compared to standard bulk EV isolation and significantly improves data structure, enhancing prediction model generalisation.
The pre-print presents the first multi-layered validation of hepatocyte EV isolation in humans, confirming liver origin through proteomic and nucleic acid markers. Key supporting proteomics data was generated in collaboration with Evotec International GmbH. Patient samples were provided by University College London, with Brian Davidson, a global leader in liver disease surgery and clinical research, contributing as a co-author. The company said the study shows its method yields robust, organ-specific multi-omics data using minimal blood volume, offering a novel scalable approach for biomarker and AI development.
Mursla Bio’s platform incorporates optimized multi-omics workflows, embedded AI pipelines, and IVD translation processes to convert complex biological signals into practical, regulatory-grade assays. These assays are deployable on standard commercial instruments using patented, PCR and ELISA-like steps designed for clinical adoption. The platform also underpins the development of EvoLiver, the company’s lead clinical programme for liver cancer surveillance in cirrhotic patients. Built on multi-omics data from more than 300 patients, EvoLiver achieved 86% sensitivity and 88% specificity on a locked, IVD-compatible assay for early-stage hepatocellular carcinoma detection, and has received Breakthrough Device Designation from the FDA.
Pierre Arsène, founder and CEO of Mursla Bio, said: “EVs are nature’s native signal enrichment system for long-distance communication between cells and organs. Our platform harnesses this biology to non-invasively access organ-specific, multi-omics data from just a small blood sample. It produces structured, biologically labelled datasets that are optimized for AI and ready to support diagnostic translation. EvoLiver is our first proof point of real-world clinical impact, and we are now expanding access to the platform to advance our pipeline and enable partnerships across other disease areas.”
Mursla Bio is expanding its pipeline and collaborations, with additional organ programmes under way in cardiometabolic, lung, and neurological indications. The company said its platform will support pharma development through dynamic patient stratification, therapeutic response monitoring, surrogate markers and molecular phenotyping across complex disease biology.
Jim Cornall is editor of Deeptech Digest and publisher at Ayr Coastal Media. He is an award-winning writer, editor, photographer, broadcaster, designer and author. Contact Jim here.
